Research projects

Ongoing research projects (2013-2014) that have received NBB tissue are listed below. The corresponding abstracts can be downloaded by clicking the links. In this list, only the affiliation of the first-mentioned researcher is mentioned. Full affiliation information is included in the abstracts.

National research projects

For the projects below, the first-mentioned researcher’s main affiliation is an organization based in the Netherlands.

• Alkemade, A., Balesar, R., Zhao, J., Swaab, D.F., and Forstmann, B.U. Amsterdam Brain and Cognition Center, University of Amsterdam. Immunocytochemical characterization of the human subthalamic nucleus.
• Bisschop, P.H., Dekker, M.J., Osterthun, W., Kwakkel, J., Anink, J.J., Boelen, A., Unmehopa U.A., Koper, J.W., Lamberts, S.W., Stewart, P.M., Swaab, D.F., and Fliers, E. Department of Endocrinology & Metabolism, Academic Medical Center, Amsterdam. Expression of 11β-hydroxysteroid dehydrogenase type 1 in the human hypothalamus.
• Bonifati, V. Department of Clinical Genetics, Erasmus MC, Rotterdam. Characterization of the FBXO7 (PARK15) protein.
• Borgers, A.J., Fliers, E., Siljee, J.E., Swaab, D.F., Van Someren, E.J., Bisschop, P.H., and Alkemade, A. Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam. Arginine vasopressin immunoreactivity is decreased in the hypothalamic suprachiasmatic nucleus of subjects with suprasellar tumors. 
• Borgers, A.J., Koopman, K.E., Bisschop, P.H., Serlie, M.J., Swaab, D.F., Fliers, E., La Fleur, S.E., and Alkemade, A.  Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam. Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects.
• Brouwer, N., Eggen, B.J., and Boddeke, H.W. Department of Neuroscience, University Medical Center Groningen. Analysis of age-related changes in gene expression in human microglia.
• Bsibsi, M., Peferoen, L.A., Holtman, I.R., Nacken, P.J., Gerritsen, W.H., Witte, M.E., Van Horssen, J., Eggen, B.J., Van der Valk, P., Amor, S., and Van Noort, J.M. Delta Crystallon, Leiden, and VU University Medical Center, Amsterdam. Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin.
• Bugiani, M., and Van der Knaap, M.S. Departments of Pediatrics / Child Neurology and Pathology, VU University Medical Centre, Neuroscience Campus Amsterdam, Amsterdam. Unraveling disease mechanisms in genetic white matter disorders.
• Bulk, M., Van der Graaf, L., Mulders, C., Natté, R., Hassan, W., Dijkstra, J., Van der Voorn, P., Van de Berg, W., Van Buchem, M., and Van der Weerd, L. Departments of Radiology & Human Genetics, Leiden University Medical Center. Pathological correlates of cortical changes in Alzheimer’s disease at ultra-high field MRI.
• Chrobok, N., Bol, J., and Van Dam, A.M. Dept. Anatomy and Neurosciences, VU University Medical Center, Amsterdam. Characterization of tissue Transglutaminase expression in active white and grey matter MS lesions.
• Gorgels, Th.G.M.F. and Bergen, A.A.B. Netherlands Institute for Neuroscience, Amsterdam, and University Eye Clinic Maastricht, MUMC+, Maastricht. Choroid Plexus and Retinal Pigment Epithelium: Two of a kind?
• Gorgels, Th.G.M.F. and Webers, C.A.B. University Eye Clinic Maastricht, MUMC+, Maastricht. From genes to glaucoma: identifying glaucoma pathways.
• Grand Moursel, L., Munting, L., Van der Graaf, L., Van Duinen, S., Van Roon-Mom, W., Van Buchem, M., Van der Maarel, S., and Van der Weerd, L. Departments of Radiology, Human Genetics, and Pathology, Leiden University Medical Center. TGFβ signalling in HCHWA-D: exploring new therapy targets against CAA.
• Hendrickx, D.A. and Huitinga, I. Department of Neuroimmunology, Netherlands Institute for Neuroscience, Amsterdam. Mechanisms of myelin phagocytosis.
• Hepp, D.H., Rozemuller, A.J.M., Groenewegen, H.J., Berendse, H.W., Foncke, E.M.J., and Van de Berg, W.D.J. Department of Anatomy and Neurosciences, Department of Neurology, VU University Medical Center, Amsterdam. The pathological substrate of visual hallucinations in Parkinson’s disease patients.
• Heutinck, K.M., Van Eden, C.G., Schuurman, K.G., Smolders, J., Ten Berge, I.J.M., Van Lier, R.A.W., Huitinga, I., and Hamann, J. Academic Medical Center, University of Amsterdam. Characterization of brain T cells in multiple sclerosis.
• Hondius, D.C., Van der Schors, R.C., Hoozemans, J.J.M., Van Nierop, P., Van der Vies, S.M., Li, K.W., Rozemuller, J.M., and Smit, A.B. Department of Pathology, VU University Medical Center, and Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Neuroscience Campus Amsterdam. Changes in the human hippocampal proteome during Alzheimer’s disease.
• Hoogerhout, P. Research Department, Institute for Translational Vaccinology (Intravacc), Bilthoven. A peptide vaccine against Parkinson's Disease.
• Hoozemans, J., Scheper, W., Lucas, J., Rozemuller, J.M. Department of Pathology, VU University Medical Center, Neuroscience Campus Amsterdam. Unfolded protein response in Huntington’s disease.
• Hoozemans, J.J.M., Meijers Heijboer, E.J., Rozemuller, J.M., Scheltens, P., Smit, A.B., and Holstege, H. Dept of Pathology, Dept. of Clinical Genetics, and Alzheimer center, VU University Medical Center, Amsterdam. 100-plus Study: Protection against cognitive decline.
• Huitinga, I., Michailidou, I., Van Strien, M.E., Van Eden, C., Fluiter, K., Neal, J.W., Giles, J., Morgan, B.P., Baas, F., and Ramaglia, V. Department of Neuroimmunology, Netherlands Institute for Neuroscience, Amsterdam. Identification of a key role for complement in neurodegeneration in multiple sclerosis.
• Ingrassia, A., Dijkstra, A.A., Van Dijk K.D., Rozemuller, A.J.M., Heutink, P., and Van de Berg, W.D.J. Dept. of Anatomy and Neurosciences and Dept. of Pathology, VU University Medical Center, Amsterdam. Chasing genes and proteins involved in disease progression in Parkinson’s disease.
• Iyer, A.M., Anink, J.J., Prabowo, A.S., Milenkovic, I., Kovács G.G., and Aronica, E. Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam.
• Kamar, S., Howlett, M., Klooster, J., Kamermans, M. Retinal Signal Processing Group, Netherlands Institute for Neuroscience, Amsterdam. Functional Properties of Photoreceptors in Cultured Human Retina.
• Klaver, R., Nijland, P., Schenk, G.J., Baks-te Bulte, L.T.G., Van het Hof, B., Van Horssen, J., De Vries, H.E., and Geurts, J.J.G. Dept. of Anatomy and Neurosciences, Dept. of Molecular cell biology and Immunology, and Dept. of Pathology, VU University Medical Center, Amsterdam. Induction of kir6.2 and KCNQ4 potassium channels in NAGM of chronic MS patients.
• Klaver, R., Popescu, V., Voorn, P., Galis-de Graaf, Y., Van der Valk, P., De Vries, H.E., Schenk, G.J., and Geurts, J.J.G. Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam. Neuronal and axonal loss in NAGM and subpial lesions in multiple sclerosis.
• Kramvis, I., Mansvelder, H., and Meredith, R. Integrative Neurophysiology Department, Center for Neurogenomics and Cognitive Research, VU University Amsterdam. Postmortem Human Brain Physiology.
• Laarman, M., Vermunt, M., Geven, G., De Laat, W., Creyghton, M., Rinkel, G., Ruigrok, Y., and Bakkers, J. University Medical Center Utrecht and Hubrecht Institute, Utrecht. Characterization of the functional relevance of genetic variants identified in genome wide association studies on intracranial aneurysm.
• Lucassen, P.J., SILS-CNS, University of Amsterdam, Amsterdam. Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients.
• Lucassen, P.J., SILS-CNS, University of Amsterdam, Amsterdam. Glucocorticoid receptor protein expression in human hippocampus in relation to age.
• Lucassen, P.J., SILS-CNS, University of Amsterdam, Amsterdam. Hippocampal proliferation in Parkinson's disease; a role for microglia?
• Lucassen, P.J., SILS-CNS, University of Amsterdam, Amsterdam. Microglia in the olfactory bulb of Parkinson's and Alzheimer's patients.
• Lucassen, P.J., SILS-CNS, University of Amsterdam, Amsterdam. Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients.
• Lucassen, P.J., SILS-CNS, University of Amsterdam, Amsterdam. Proliferation in the Alzheimer hippocampus.
• Lucassen, P.J., SILS-CNS, University of Amsterdam, Amsterdam. Stress hormone receptors in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients.
• Luchetti, S., Cossu, S., Sluiter, A., Liere, Ph., Hofstee, M., Aronica, E., Schumacher, M., Swaab, D.F., and Huitinga, I. Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam. Neurosteroids as neuroprotective, pro-myelinating and anti-inflammatory agents in Multiple Sclerosis.
• Luchetti, S., Van Eden, C.G., Schuurman, K., Van Strien, M.E., Swaab, D.F., and Huitinga, I. Department of Neuroimmunology, Netherlands Institute for Neuroscience, Amsterdam. Gender differences in multiple sclerosis: induction of estrogen signaling in male and progesterone signaling in female lesions.
• Luchetti, S., Verwer, R., Sluiter, A., Liere, Ph.,  Huitinga, I., Schumacher, M., and Swaab, D. Neuroimmunology Research Group and Neuropsychiatric Disorders Group, Netherlands Institute for Neuroscience, Amsterdam. Neurosteroids as potential neuroprotective agents in Parkinson’s disease: implications for new therapeutic strategies.
• Moors, T.E., Paccioti, S., Ingrassia, A.M.T., Chiasserini, D., Eusebi, P., Calabresi, P., Parnetti, L., Beccari, T., Van de Berg, W.D.J. Dept. Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam. Evaluation of changes in GCase activity and substrate levels in human brain from PD / Lysosomal enzyme activities in postmortem brain tissue of patients with Lewy Body Diseases.
• Peferoen, L.A., Vogel, D.Y., Ummenthum, K., Breur, M., Heijnen, P.D., Gerritsen, W.H., Peferoen-Baert, R.M., Van der Valk, P., Dijkstra, C.D., and Amor, S. Department of Pathology, VU University Medical Center, Amsterdam. Activation status of human microglia is dependent on lesion formation stage and remyelination in multiple sclerosis.
• Pelzer, N., Klever, R.R., Ferrari, M.D., Van den Maagdenberg, A.M.J.M., Van Duinen, S.G., and Terwindt , G.M. Department of Neurology, Leiden University Medical Center, Leiden. Pathophysiology of Retinal Vasculopathy and Cerebral Leukodystrophy – involvement of endothelial and pericyte dysfunction.
• Philippens, I., Ormel, P., Baarends, G., and Remarque, E. Biomedical Primate Research Centre (BPRC), Rijswijk. Acceleration of amyloidosis by inflammation in the amyloid-beta Marmoset monkey model of Alzheimer’s disease.
• Popescu, V., Klaver, R., Versteeg, A., Voorn, P., Twisk, J.W.R., Barkhof, F., Geurts, J.J.G., and Vrenken, H. Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam. Post-mortem validation of MRI cortical volume measurements in MS.
• Popescu, V., Klaver, R., Voorn, P., Galis-de Graaf, Y., Knol, D.L., Twisk, J.W.R., Versteeg, A., Schenk, G.J., Van der Valk, P., Barkhof, F., De Vries, H.E., Vrenken, H., and Geurts, J.J.G.. Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam. What drives MRI-measured cortical atrophy in multiple sclerosis?
• Rizzu, P., Cortez, L.P., Rizzu ,P., Francescatto , M., Sanchez  ,J.S., and Heutink, P. Medical Genomics, VU Medical Center, Amsterdam. Regional differences in gene expression and promoter usage in aged human brains.
• Schenk, G.J., Klaver, R., Klauser, A., Tsutsui, S., Poon, K., Van Minnen, J., Stys P.K., and Geurts, J.J.G. Dept. of Anatomy & Neuroscience, Div. of Clinical Neuroscience, VU University Medical Center, Amsterdam. Pathobiology of MS: complex interplay between degeneration and inflammation.
• Schwab, B.C., Van Gils, S.A., Heida , T., and Van Wezel, R.J.A. Applied Analysis and Mathematical Physics, University of Twente, Enschede. A Possible Role of Neural Gap Junctions in Parkinson's disease Pathology.
• Siljee, J.E., Unmehopa, U.A., Kalsbeek, A., Swaab, D.F., Fliers, E., and Alkemade, A. Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam. Melanocortin 4 receptor distribution in the human hypothalamus.
• Smit, A.B. et al. Center for Neurogenomics and Cognitive Research, VU University Amsterdam. Prefrontal cortex proteomics analysis in Schizophrenia.
• Sneeboer, M.A.M., Litjens, M., Melief, J., Van der Doef, T., Palmen, S.J.M.C., Hol, E.M., Kahn R.S. and De Witte, L.D. UMC Utrecht Brain Center Rudolf Magnus, Utrecht. The role of microglia in the pathogenesis of schizophrenia.
• Stedehouder, J., Mientjes, E.J., Demmers, J., Verdijk, R., Kros, M., Elgersma, Y., and Kushner, S.A. Department of Psychiatry, Erasmus MC, Rotterdam. Extracellular Matrix Abnormalities in Schizophrenia.
• Van der Pol, S. and Van Horssen, J. Dept. of Molecular Cell Biology and Immunology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam. Establish a human in vitro model mimicking grey matter MS pathology.
• Van Horssen, J., and Huitinga, I. Dept Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam.
• Van Luijn, M.M., Kreft, K.L., Jongsma, M.L.M., Mes, S.W., Wierenga-Wolf, A.F., Van Meurs, M., Melief, M.J., Van der Kant, R., Janssen, L., Janssen, H., Priatel, J.J., Tan, R., Neefjes, J., Laman, J.D., and Hintzen, R.Q. Department of Immunology, MS Centre ErasMS, Erasmus MC, Rotterdam. CLEC16A shows increased expression in multiple sclerosis and functions as a direct regulator of the HLA class II antigen presentation pathway.
• Van Nierop, G.P., Hintzen, R.Q, and Verjans, G.M.G.M. Department of Viroscience and the ErasMS center at the department of Neurology, Erasmus MC, Rotterdam. Specificity and phenotype of T cells in multiple sclerosis lesions.
• Van Riel, D., Leijten, L., Osterhaus A., and Kuiken, T. Department of Viroscience, Erasmus MC, Rotterdam. Influenza virus entry into the CNS via the olfactory nerve.
• Van Strien, M.E. Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht. Neural stem cells in the spinal cord of Multiple Sclerosis patients.
• Van Strien, M.E., Sluijs, J.A., and Hol, E.M. Dept. Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht. Towards mobilizing the brain’s own neural stem cells to restore striatal dysfunction in Parkinson patients.
• Van Swieten, J.C. et al. Department of Neurology, Erasmus Medical Center, Rotterdam. AD epigenetics
• Van Swieten, J.C. et al. Department of Neurology, Erasmus Medical Center, Rotterdam. Clinicopathological correlation in FTD.
• Van Swieten, J.C. et al. Department of Neurology, Erasmus Medical Center, Rotterdam. PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.
• Van Velzen, M., Osterhaus, A.D.M.E. and Verjans, G.M.G.M. Department of Viroscience, Erasmus MC, Rotterdam. Latent herpes simplex virus infections of sensory neurons of the human peripheral nervous system.
• Veerhuis, R. and Hoozemans, J. Dept. of Clinical chemistry, Alzheimer center, and dept. of Pathology, VU university medical center, Amsterdam. Analysis of mediators of inflammation in Alzheimer's disease.
• Wilhelmus, M.M.M. and Drukarch, B. Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam. Distribution of cross-linking enzymes, their activity and their substrates in Alzheimer’s disease brain.

International research projects

• Adav, S.S. and Sze, S.K. School of Biological Sciences, Nanyang Technological University, Singapore. Brain site-specific protein deamidation in Alzheimer’s disease.
• Albrecht, S., Ghelman,  J., Kemming, C., and Kuhlmann, T. Institute of Neuropathology, University Hospital Münster, Münster, Germany. Extent of remyelination in spinal cord lesions compared to brain lesions.
• Bergström, J. and Almandoz-Gil, L. Department of Public Health and Caring Sciences, Uppsala University, Sweden. Immunohistochemical analysis of Lewy body pathology using polyclonal alpha-synuclein antibodies with the aim to improve immunological detection.
• Bernis, M.E. and  Tamgüney, G. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. Assessment of prion-like behavior of pathologic protein aggregates from ALS patients.
• Blázquez C., Chiarlone A., Resel E., Ruiz, A., Galve-Roperh I., and Guzmán, M. Dept Biochemistry and Molecular Biology I, School of Biology; CIBERNED, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas, Complutense University, Madrid, Spain. Neuroprotective role of CB1 cannabinoid receptor in Huntington’s disease and experimental models.
• Bogie, J.F.J., Jorissen, W., Mailleux, J., Nijland, Ph.G.,  Zelcer, N., Vanmierlo, T., Van Horssen2, J., Stinissen, P., Hellings, N., and Hendriks, J.J.A. Biomedical Research Institute, School of Life Sciences, Hasselt University / Transnational University Limburg, Diepenbeek, Belgium. Myelin alters the inflammatory phenotype of macrophages by activating PPARs.
• Bogie, J.F.J., Vanmierlo, T., Van Horssen, J., Stinissen, P., Hellings, N. and Hendriks, J.J.A. Hasselt University / Transnational University Limburg, Biomedical Research Institute, School of Life Sciences, Diepenbeek, Belgium. Induction of COLEC12 expression on myelin-phagocytosing macrophages and in active MS lesions.
• Breuer, J., Schneider-Hohendorf, T., Schwab, N., and Wiendl, H. Department of Neurology, University of Münster, Münster, Germany. Analysis of the expression of laminin alpha-4 on choroid plexus tissue.
• Breuer, J., Schneider-Hohendorf, T., Schwab, N., and Wiendl, H. Department of Neurology, University of Münster, Münster, Germany. Analysis of the expression of VLA2 on lymphocytes in Multiple Sclerosis lesions.
• Broux, B., Mizee, M.R., Vanheusden, M., Van der Pol, S., Van Horssen, J., Van Wijmeersch, B., Somers, V., De Vries, H.E., Stinissen, P., and Hellings, N. Biomedical Research Institute, Hasselt University, Belgium. Interleukin-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosis.
• Broux, B., Peter, Ch., Bourbonnière, L., Duquette, P., Korn, Th., Stinissen, P., Prat, A., and Hellings, N. Biomedical Research Institute, Hasselt University, Belgium. The unexplored role of interleukin-24 in multiple sclerosis.
• Bruch, J., Xu, H., De Andrade, A., and Höglinger, G. German Centre for Neurodegenerative Diseases (DZNE), Tubingen, Germany. Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation.
• Chalmoukou, K. Neuroimmunology Unit, Dept. of Pathophysiology-Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Determination of human anti-MOG antibodies binding patterns in optic nerves.
• Choi, E.Y. Lim, J.H., Neuwirth, A., Economopoulou, M., Chatzigeorgiou, A., Chung, K.J., Bittner, S., Lee, S.H., Langer, H., Samus, M., Kim, H., Cho, G.S., Ziemssen, T., Bdeir, K., Chavakis, E., Koh, J.Y.,  Boon, L., Hosur, K., Bornstein, S.R., Meuth, S.G., Hajishengallis, G., and Chavakis, T. Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Republic of Korea. Identification of developmental endothelial locus-1 (Del-1) as a homeostatic factor in the central nervous system limiting multiple sclerosis.
• De Bock, L., Fraussen, J., and Somers, V. Biomedical Research Institute, Hasselt University, Belgium, and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium. Sperm-associated antigen 16 is a novel target of the humoral autoimmune response in MS.
• Delalle, I. Boston University School of Medicine, Boston, MA, USA. Deregulated exosomal microRNA as a biomarker in bipolar disorder. 
• Delalle, I., and Tsai, L.H. Boston University School of Medicine, Boston, MA, USA, and Massachusetts Institute of Technology, Cambridge, MA, USA. Identification of circuits that benefit from cholinergic intervention in cognitive decline during Alzheimer Disease progression.
• Deleersnijder, A., Van Rompuy A.S., Desender, L., Pottel, H., Buée, L., Debyser, Z., Baekelandt V., and Gerard, M. Laboratory of Neurobiology and Gene Therapy, K. U. Leuven, Leuven, Flanders, Belgium. Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of α-synuclein aggregation.
• Demuyser, T., Bentea, E., Deneyer, L., Albertini, G., Van Liefferinge, G.J., Merckx, E., Massie, A., and Smolders, I. Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. The cystine/glutamate antiporter as a potential novel target to modulate the stress response.
• Dohler, F., Sepulveda-Falla, D., Krasemann, S., Altmeppen, H., Dobert, J., Zerr, I., Matschke, J., and Glatzel, M. Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Characterization of the interaction of the cellular Prion Protein (PrPC) with beta-sheet rich protein aggregates in Dementia.
• Dzamko, N., Nichols, J., Holten, J., Van de Berg, W., Takao, M., Murayama, S., and Halliday, G. Neuroscience Research Australia, University of NSW, Sydney, Australia. Leucine-rich repeat kinase 2 expression in postmortem Parkinson’s disease brain.
• Eberhardt, E., Havlicek, S., Schmidt, D., Winner, B., and Lampert, A. Institute of Physiology and Pathophysiology, and Department of Anesthesiology, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany. Pattern of functional TTX-resistant sodium channels reveals developmental stage of human iPS- and ES cell-derived nociceptors.
• Ettle, B., and Winkler, J. Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany. Role of oligodendrocyte progenitors in Multiple System Atrophy.
• Fernandez-Ruiz, J., Rodriguez-Cueto, C., Hernández-Gálvez, M., and Gómez-Ruiz, M. Instituto Universitario de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain. Evaluation of the endocannabinoid receptors and enzymes in the postmortem cerebellum of different SCA patients.
• Francescatto, M., Rizzu, P., Sanchez, J.S., Heutink, P., and the Fantom 5 consortium. German Center for Neurodegenerative Diseases (DZNE), Tubingen, Germany. Profiling the promoterome of the human brain.
• Fraussen, J., and Somers, V. Biomedical Research Institute, Hasselt University, Belgium, and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium. Antibody-independent effects of B cells in multiple sclerosis (MS).
• Galter, D. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Expression and quantification of candidate genes of Alzheimer’s disease in brain regions primarily affected by disease.
• Gao, S.F., Jin, L., Ji, D.F., Wang, J., Cao, Y.J., Zhou, X.P., and Yu, R.T. Institute of Nervous system Diseases, Xuzhou Medical College, Xuzhou, P.R. China. The role of CAPON-mediated hypothalamic nNOS-NO system in the pathogenesis of depression.
• Grosser, C., Neumann, L., Horsthemke, B., Zeschnigk, M., and Van de Nes, J. Institute of Human Genetics and Institute of Neuropathology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Methylation analysis of SST and SSTR4 promotors in the neocortex of Alzheimer’s disease patients.
• Großmann, U., Zeisig, V., Brust, P., Deuther-Conrad, W.,  Patt, M., Schildan, A., Sabri, O., and Barthel, H. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany. Autoradiographic investigation of α7 nACh-receptor expressionin the Alzheimer brain.
• Guzmán, E.A., Bouter, Y., Richard, B.C., Lannfelt, L., Ingelsson, M., Paetau, A., Verkkoniemi, A., Wirths, O., and Bayer, T.A. Department of Psychiatry, University Medicine Goettingen, Goettingen, Germany.  Abundance of Aβ5-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer´s Disease.
• Houlden, H. 6th floor DNA laboratory, Institute of Neurology, London. Genetic Analysis of Inherited Leukodystrophies: Genotype-Phenotype Correlations in the CSF1R Gene.
• Hu, H. Institute of Neuroscience Chinese Academy of Sciences, Shanghai, P.R. China. A high-throughput quantitative proteomics approach to identify altered synaptic protein content in an animal model of depression.
• Janssens, K., Van den Haute, Ch., Baekelandt, V., Lucas, S., Van Horssen, J., Somers, V., Van Wijmeersch, B., Stinissen, P., Hendriks, J.J.A., Slaets, H., and Hellings, N. Biomedical Research Institute, Hasselt University, Belgium. Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis.
• Jones, E., Ballard, C., and Doherty, P. Wolfson Centre for Age-Related Diseases, King’s College London, London, United Kingdom. Functional Genetic Analysis: Mechanisms of Dementia in People with Down syndrome.
• Kalmar, B., Greensmith, L., and Fisher, E. UCL Institute of Neurology, Queen Square, London, United Kingdom. Lower motor neuron pathology in Down’s Syndrome.
• Kaut, O., and Hurlemann, R. Dept. of Neurology and Dept. of Psychiatry, University of Bonn, Germany. Genome-wide DNA methylation analysis of depression in human braim samples.
• Leoni, E., Zubiri, E., Ward, M., Pike, I., and Malaspina, A. Blizard Institute, QMUL and Proteome Sciences, London, UK. TMT-proteomic work-flow for tissue-fluid interface biomarkers discovery in amyotrophic lateral sclerosis.
• Léveillard, T. et al. Department of Genetics, Institut de la Vision, University Pierre et Marie Curie, Paris, France. Implication of the Nucleoredoxin like gene 2 (NXNL2) in the patholphysiology of Alzheimer’s disease.
• Liebsch, F., Kulic, L., Konietzko, U., Scheltens, P., Hock, C., and Multhaup, G. Pharmacology and Therapeutics, McGill University, Montreal, Canada. Diagnostic Potential of Aβ-clearance Intermediates in Elderly Subjects at Risk for Alzheimer’s Disease.
• Lu, J., Zha, J., Balesar, R., Fronczek, R., Bao, A., and Swaab, D.F. Department of Neurobiology; Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, P.R. China, and Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. Orexin-A (hypocretin-1) changes in depression and suicide: gender differences.
• Mailleux, J., Vanmierlo, Bogie, J., Wouters, E., Stinissen, P., Hendriks, J., and van Horssen, J. Hasselt University, Biomedical Research Institute, School of Life Sciences, Diepenbeek, Belgium. Liver X receptor activation in MS lesions.
• Marcello, E., Musardo, S., Pelucchi, S., Mellone, M., Gardoni, F., and Di Luca, M. Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy. Protein-protein interactions in Alzheimer's disease.
• Mulder, J. et al. Science for life Laboratory, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. The next step in Biomarker discovery. Linking genes to cells and disease processes involved in AD and DLB.
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