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Expertise

We will provide tailored solutions designed to answer research questions from biotechnology and pharmaceutical companies. Uniquely positioned between the world-renowned professional biobank and excellent neuroscience research facilities, NBB-RS will guide partners from research project definition, to optimal tissue selection and custom sample processing and analyses. Together we strive to advance target discovery, preclinical and translational research for neurological and psychiatric conditions.

The first research activities of NBB-RS are currently operational. Our techniques are constantly in development and will be improved according to the latest developments and insights. Thanks to our position on the forefront of neuroscience research and connected with excellent Dutch neuroscience institutes, we can expand our services, analysis methods tailored to your project.

Publications

Our products and services are built on validated protocols and scientific expertise of the NBB staff. Overview of reference literature:

1. Böttcher C, van der Poel M, Fernández-Zapata C, Schlickeiser S, Leman JKH, Hsiao CC, et al. Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis. Acta Neuropathol Commun. 2020 Aug 18;8(1):136.

2. Mizee MR, Poel M van der, Huitinga I. Purification of cells from fresh human brain tissue: primary human glial cells. In: Handbook of Clinical Neurology [Internet]. Elsevier; 2018 [cited 2022 Jan 24]. p. 273–83. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780444636393000190

3. van der Poel M, Ulas T, Mizee MR, Hsiao CC, Miedema SSM, Adelia  null, et al. Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes. Nat Commun. 2019 Mar 13;10(1):1139.

4. Melief J, Koning N, Schuurman KG, Van De Garde MDB, Smolders J, Hoek RM, et al. Phenotyping primary human microglia: tight regulation of LPS responsiveness. Glia. 2012 Oct;60(10):1506–17.

5. Lopes K de P, Snijders GJL, Humphrey J, Allan A, Sneeboer MAM, Navarro E, et al. Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies. Nat Genet. 2022 Jan;54(1):4–17.

6. Fransen NL, Hsiao CC, van der Poel M, Engelenburg HJ, Verdaasdonk K, Vincenten MCJ, et al. Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions. Brain J Neurol. 2020 Jun 1;143(6):1714–30.

7. Hendrickx DAE, van Scheppingen J, van der Poel M, Bossers K, Schuurman KG, van Eden CG, et al. Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions. Front Immunol [Internet]. 2017 [cited 2022 Apr 25];8. Available from: https://www.frontiersin.org/article/10.3389/fimmu.2017.01810

8. Michailidou I, Willems JGP, Kooi EJ, van Eden C, Gold SM, Geurts JJG, et al. Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus. Ann Neurol. 2015 Jun;77(6):1007–26.

9. Geut H, Hepp DH, Foncke E, Berendse HW, Rozemuller JM, Huitinga I, et al. Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series. Acta Neuropathol Commun. 2020 Mar 26;8(1):39.

 

 

 

Expertise